MonoMethyl auristatin F
CAS No. 745017-94-1
MonoMethyl auristatin F ( Monomethyl auristatin F; MMAF )
Catalog No. M17587 CAS No. 745017-94-1
Monomethyl auristatin F, an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 35 | In Stock |
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5MG | 58 | In Stock |
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10MG | 87 | In Stock |
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25MG | 132 | In Stock |
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50MG | 178 | In Stock |
|
100MG | 250 | In Stock |
|
200MG | 376 | In Stock |
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500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameMonoMethyl auristatin F
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NoteResearch use only, not for human use.
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Brief DescriptionMonomethyl auristatin F, an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
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DescriptionMonomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself.
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SynonymsMonomethyl auristatin F; MMAF
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorCytotoxicity( Karpas 299 cell)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number745017-94-1
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Formula Weight731.98
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Molecular FormulaC39H65N5O8
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Purity98%
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Solubility——
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SMILESCC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
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Chemical Name((2R,3R)-3-((2S)-1-((3R,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tai, Y. T.Blood. 123 (20): 3128–38.
molnova catalog
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